ASSOCIATION BETWEEN QUANTITATIVE ANALYSES OF PERIODONTAL PATHOGENS AND THE DEPTH OF PERIODONTAL POCKETS


Effects of pre-existing anti-adenovirus antibodies on transgene expression levels and therapeutic efficacies of arming oncolytic adenovirus

Abstract Oncolytic adenoviruses (OAds), most of Draught Excluder which are based on species C human adenovirus serotype 5 (Ad5) (OAd5), have recently received much attention as potential anticancer agents.High seroprevalence of anti-Ad5 neutralizing antibodies is a major hurdle for Ad5-based gene therapy.However, the impacts of anti-Ad5 neutralizin

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Analysis of pools of targeted Salmonella deletion mutants identifies novel genes affecting fitness during competitive infection in mice.

Pools of mutants of minimal complexity but maximal coverage of genes of interest facilitate screening for genes under selection in a particular environment.We constructed individual deletion mutants in 1,023 Salmonella enterica serovar 1182 Typhimurium genes, including almost all genes found in Salmonella but not in related genera.All mutations wer

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